Abstract
The correlation between endo-perio lesions and systemic diseases and to analyze their association with age and gender distribution is of interest. Hence, a total of 800 participants aged between 25 and 75 years. Patients were categorized based on the presence or absence of systemic diseases, including diabetes, hypertension, cardiovascular disorders, arthritis and altered kidney/liver function. Detailed clinical and radiographic evaluations were conducted to classify lesions as primary endodontic, primary periodontal, or true combined lesions. The study underscores a strong correlation between systemic diseases and the severity of endo-perio lesions, especially in older males.