Abstract
A repetitive and wide use of chemical antibiotics has brought a serious threat in the biomedical and clinical sectors by the emergence of multidrug resistant pathogens. Plants have secondary metabolites that make them suitable candidate for natural antimicrobial agent without any side effect. In this study, we assessed comparative antibacterial and antifungal effects of extracts from four Indigenous plants (Nerium sp; Mentha sp; Aloe vera and Eucalyptus sp). Total phenolic and flavonoid content were extracted by microwave-assisted extractor and used for phytochemical assay. Antimicrobial experiment was done by micro dilution technique. A post hoc analysis inbuilt with one-way ANOVA test was used for the compilation of antibiotic sensitivity data and percent inhibition. Total phenolic content was significantly high in Mentha sp. and low in Nerium sp. (All p < 0.05). In antibacterial and antifungal activity higher concentrations of extracts showed a strong activity, which was as good as antibiotics used as control. Results from Eucalyptus sample showed a significant growth reducing capability even at lower concentrations. This study concludes that the plant extracts can be used to treat microbial infections with almost same efficacy as antibiotics and with a lower chance of resistance development.