Successful Alternative Administration of Sonidegib in a Patient with Gorlin-Goltz Syndrome and Dysphagia: A Case Report

成功采用索尼德吉替代疗法治疗戈林-戈尔茨综合征合并吞咽困难患者:病例报告

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Abstract

INTRODUCTION: Activation of the Hedgehog (HH) pathway is a key factor in the development of basal cell carcinoma. CASE PRESENTATION: Approved HH pathway inhibitors, like vismodegib and sonidegib, are supplied in capsule form. Patients who suffer from dysphagia may have problems swallowing these medications. CONCLUSION: This case report describes the successful use of an alternative administration of sonidegib in a patient with Gorlin-Goltz syndrome and dysphagia.

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