Abstract
RATIONALE: Guillain-Barré syndrome (GBS) is a self-limiting immune-mediated neuropathy, pharyngeal-cervical-brachial (PCB) and paraparetic variants are rare variants of GBS spectrum disorders, and there are no reports of their coexistence. PATIENT CONCERNS: The patient had an episodic course with progressive exacerbation, with frequent episodes of weakness and soreness in both lower limbs as the main complaints, and presented with dysphagia in this occurrence. DIAGNOSES: The patient was diagnosed with a case of GBS presenting features of both PCB and paraparetic variants. INTERVENTIONS: The patient was treated with human immunoglobulin and Vitamin B1 and vitamin B12 nutritional neurotherapy. OUTCOMES: Owing to the clear diagnosis of GBS with features of both PCB and paraparetic variants, the patient received an intravenous infusion of 34 g of human immunoglobulin, which was received for 5 consecutive days during which the above symptoms did not occur. LESSONS: A case of an anti-GT1a antibody-positive GBS variant with episodic onset is reported in this article. Rare and atypical symptoms are easy to misdiagnose clinically, thus the clinical data, diagnosis and treatment were analyzed to improve the understanding of the disease by clinicians.