Abstract
Acute adult supraglottitis is a serious and potentially life-threatening condition marked by inflammation of the supraglottic structures, posing a significant risk for rapid airway compromise. This case series highlights the varied presentations and management challenges associated with adult supraglottitis. The four cases involve adult males, most with uncontrolled diabetes mellitus, presenting with symptoms such as difficulty breathing, sore throat, dysphagia, and voice changes. Diagnostic approaches included soft-tissue neck radiographs and video laryngoscopy, with common findings of an edematous epiglottis and "thumbprint" sign. Management strategies ranged from conservative treatment with antibiotics and steroids to emergent airway interventions like tracheostomy. These cases underscore the importance of early diagnosis, close monitoring, and tailored treatment to prevent severe outcomes. The series emphasizes the need for high clinical suspicion and prompt action in cases of adult supraglottitis, especially given its potential for rapid deterioration and significant morbidity.