Abstract
Bone defects caused by trauma, infection, or congenital anomalies remain a significant challenge in orthopedic and dental practice, necessitating innovative strategies to enhance healing and functional restoration. This systematic review by Pagani et al synthesizes evidence on the synergistic role of synthetic biomaterials, such as hydroxyapatite (HA) and β-tricalcium phosphate (β-TCP), combined with fibrin derivatives in bone regeneration. Analyzing 21 studies, the authors demonstrate that HA and β-TCP composites exhibit superior osteoconductivity and biocompatibility when integrated with fibrin sealants or platelet-rich fibrin, promoting cellular adhesion, osteogenic differentiation, and accelerated healing. While these studies underscore the potential of these biomaterial-fibrin hybrids, limitations such as variability in fibrin preparation, lack of long-term data, and insufficient standardization hinder clinical translation. This editorial contextualizes these findings within the evolving landscape of regenerative medicine, emphasizing the need for optimized formulations, interdisciplinary collaboration, and robust clinical trials to bridge laboratory innovation to bedside application.