Abstract
Cotard's delusion is a rare and complex condition marked by profound detachment from reality and nihilistic beliefs about decay and mortality, often stemming from underlying psychiatric or neurological issues. In the case of Mr. B, a 44-year-old man with a history of seizure disorder and major depressive disorder (MDD) with psychotic features, his delusions included beliefs that his right leg was decaying and that he was deceased. Despite treatment attempts with various combinations of antidepressants and antipsychotics, his delusions worsened, achieving substantial relief only through venlafaxine monotherapy. This outcome, highlighting the potential inefficacy of antipsychotics and the success of venlafaxine, underscores the need for better understanding and additional pharmacological research into Cotard's delusion, particularly within the context of MDD with psychotic features. The exact mechanism through which venlafaxine achieved a positive response remains unknown, necessitating further comprehensive studies.