Abstract
Background/Objectives: Healthcare-associated infections involving surgical sites, skin trauma, and devices penetrating the skin are a frequent source of increased expense, hospitalization periods, and adverse outcomes. Medical adhesives are often employed to help protect compromised skin from infection and to secure medical devices, but adhesives can become contaminated by pathogens, exposing wounds, surgical sites, and medical devices to colonization. We aimed to incorporate ceragenins, a class of antimicrobial agents, into silicone- and polyacrylate-based adhesives with the goal of reducing adhesive contamination and subsequent infections. Methods: Three adhesives were developed and evaluated for the release of ceragenins, antimicrobial efficacy, adhesive strength, and dermal irritation. Results: Elution profiles over two weeks showed a high initial release followed by steady, long-term release. Standard microbial challenges of the adhesives by methicillin-resistant Staphylococcus aureus, Pseudomonas aeruginosa, or Candida albicans demonstrated microbial reduction for 6 to 68 days. Lap shear adhesive strength was not reduced for polyacrylate adhesives containing ceragenins, and no dermal irritation was observed in an in vivo model. Conclusions: Ceragenin-containing adhesive materials appear well suited for prevention of bacterial and fungal infections associated with medical devices and bandages.