Harmonin inhibits presynaptic Cav1.3 Ca²⁺ channels in mouse inner hair cells

Harmonin抑制小鼠内毛细胞突触前Cav1.3 Ca²⁺通道

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Abstract

Harmonin is a scaffolding protein that is required for normal mechanosensory function in hair cells. We found a presynaptic association of harmonin and Ca(v)1.3 Ca(2+) channels at the mouse inner hair cell synapse, which limits channel availability through a ubiquitin-dependent pathway.

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