Stable engineered vascular networks from human induced pluripotent stem cell-derived endothelial cells cultured in synthetic hydrogels

在合成水凝胶中培养的人类诱导多能干细胞衍生的内皮细胞形成的稳定工程血管网络

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作者:Matthew R Zanotelli, Hamisha Ardalani, Jue Zhang, Zhonggang Hou, Eric H Nguyen, Scott Swanson, Bao Kim Nguyen, Jennifer Bolin, Angela Elwell, Lauren L Bischel, Angela W Xie, Ron Stewart, David J Beebe, James A Thomson, Michael P Schwartz, William L Murphy

Significance

Human induced pluripotent stem cell-derived endothelial cells (iPSC-ECs) cultured in synthetic hydrogels self-assemble into capillary networks through mechanisms consistent with in vivo vascular morphogenesis.

Statement of significance

Human induced pluripotent stem cell-derived endothelial cells (iPSC-ECs) cultured in synthetic hydrogels self-assemble into capillary networks through mechanisms consistent with in vivo vascular morphogenesis.

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