Abstract
Effective scar prevention and treatment remain a clinical challenge in the field of surgery, while concept innovation and technological progress will be the key to making the breakthrough. Although tissue remodeling is an important part of wound healing process, natural healing often results in scar formation. The fundamental reason is that the natural tissue remodeling is not effective enough. The author proposes that the strategy of interventional tissue remodeling can be used for scar prevention and treatment. This strategy involves artificially interfering the wound healing process using various feasible means such as laser and microplasma therapy, drugs, bioactive molecules as well as tissue regenerative methods. Therefore, the natural wound healing process can be transformed towards the process of tissue regeneration to a certain extent. As a result, it is likely to achieve better tissue remodeling effect that is not possible by the natural remodeling process. Based on reported literature and the author's own clinical experience, this article reviews the feasible application areas of interventional tissue remodeling strategies in the field of scar prevention and treatment along with clinical evidence of case report, and hopes to draw attention from peer colleagues to this clinical challenge in order to establish such an effective strategy with further clinical validation by additional evidence.