Systemic immune modulation by stereotactic radiotherapy in early-stage lung cancer
立体定向放射治疗对早期肺癌的系统性免疫调节作用
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作者:Eleni Gkika # ,Elke Firat # ,Sonja Adebahr ,Erika Graf ,Ilinca Popp ,Gianluca Radicioni ,Simon S Lo ,Ursula Nestle ,Nils H Nicolay ,Gabriele Niedermann ,Dan G Duda ,Anca-L Grosu
| 期刊: | npj Precision Oncology | 影响因子: | 6.800 |
| 时间: | 2023 | 起止号: | 2023 Mar 2;7(1):24. |
| doi: | 10.1038/s41698-023-00358-z | 研究方向: | 肿瘤 |
| 疾病类型: | 肺癌 | |
Abstract
We performed a prospective study of circulating immune cell changes after stereotactic body radiotherapy (SBRT) in 50 early-stage NSCLC patients. We found no significant increase in CD8+ cytotoxic T lymphocytes at first follow-up (the primary endpoint) but detected a significant increase in expanding Ki-67+CD8+ and Ki-67+CD4+ T-cell fractions in patients treated with 10 Gy or less per fraction. SBRT can induce significant expansion in circulating effector T-cells immediately post-treatment.
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