Abstract
SUMMARY: Correlating disease mutations with clinical and phenotypic information such as drug response or patient survival is an important goal of personalized cancer genomics and a first step in biomarker discovery. HyperModules is a network search algorithm that finds frequently mutated gene modules with significant clinical or phenotypic signatures from biomolecular interaction networks. AVAILABILITY AND IMPLEMENTATION: HyperModules is available in Cytoscape App Store and as a command line tool at www.baderlab.org/Sofware/HyperModules. CONTACT: Juri.Reimand@utoronto.ca or Gary.Bader@utoronto.ca SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.