Genetic mapping of brain plasticity across development in Williams syndrome: ERP markers of face and language processing

威廉姆斯综合征患者发育过程中脑可塑性的遗传图谱:面部和语言处理的ERP标记

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Abstract

In Williams Syndrome (WS), a known genetic deletion results in atypical brain function with strengths in face and language processing. We examined how genetic influences on brain activity change with development. In three studies, event-related potentials (ERPs) from large samples of children, adolescents, and adults with the full genetic deletion for WS were compared to typically developing controls, and two adults with partial deletions for WS. Studies 1 and 2 identified ERP markers of brain plasticity in WS across development. Study 3 suggested that, in adults with partial deletions for WS, specific genes may be differentially implicated in face and language processing.

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