Abstract
Electroconvulsive therapy (ECT) has been widely used to treat the major depressive disorder (MDD), especially for treatment-resistant depression. However, the neuroanatomical basis of ECT remains an open problem. In our study, we combined the voxel-based morphology (VBM), resting-state functional connectivity (RSFC) and granger causality analysis (GCA) to identify the longitudinal changes of structure and function in 23 MDD patients before and after ECT. In addition, multivariate pattern analysis using linear support vector machine (SVM) was applied to classify 23 depressed patients from 25 gender, age and education matched healthy controls. VBM analysis revealed the increased gray matter volume of left superficial amygdala after ECT. The following RSFC and GCA analyses further identified the enhanced functional connectivity between left amygdala and left fusiform face area (FFA) and effective connectivity from FFA to amygdala after ECT, respectively. Moreover, SVM-based classification achieved an accuracy of 83.33%, a sensitivity of 82.61% and a specificity of 84% by leave-one-out cross-validation. Our findings indicated that ECT may facilitate the neurogenesis of amygdala and selectively enhance the feedforward cortical-subcortical connectivity from FFA to amygdala. This study may shed new light on the pathological mechanism of MDD and may provide the neuroanatomical basis for ECT.