Abstract
CONTEXT: Agent abuse is a dire predicament worldwide. Learning and memory deficits stemming from the withdrawal of such agents is an increasingly burning issue for researchers. EVIDENCE ACQUISITION: The present review revisits the literature generated by far pertaining to the research on memory and cognition deficiencies after withdrawal of agent abuse and corresponding mechanisms. RESULTS: Deficiency on spatial memory, episodic memory and working memory are common after withdrawal of agent abuse. CONCLUSIONS: The present review suggests that memory dysfunction may result from withdrawal of agent abuse.