Abstract
Hematology plays a critical role in diagnosing and managing a wide range of blood-related disorders. The manual interpretation of blood smear images, however, is time-consuming and highly dependent on expert availability. Moreover, it is particularly challenging in remote and resource-limited settings. In this study, we present an AI-driven system for automated blood cell anomaly detection, combining computer vision and machine learning models to support efficient diagnostics in hematology and telehealth contexts. Our architecture integrates segmentation (YOLOv11), classification (ResNet50), transfer learning, and zero-shot learning to identify and categorize cell types and abnormalities from blood smear images. Evaluated on real annotated samples, the system achieved high performance, with a precision of 0.98, recall of 0.99, and F1 score of 0.98. These results highlight the potential of the proposed system to enhance remote diagnostic capabilities and support clinical decision making in underserved regions.