Abstract
OBJECTIVE: To study the composition and diversity of microorganisms in skin lesions of patients with facial acne and back acne, analyze the relationship between microorganisms and different parts of acne. METHODS: A total of 30 facial acne patients, 30 back acne patients, and 30 healthy controls were included. Comprehensive data on demographics, skin conditions, and state of life were collected. Skin microbiota samples were obtained using standardized protocols, through high-throughput microbial sequencing and bioinformatics analysis, to assess microbiota diversity, composition, and function, as well as their correlations with skin characteristics. RESULTS: The diversity of skin microbiota of back acne patients decreased significantly, and the abundance of p_actinomycetes and o_propionate bacteria increased significantly. They are closely related to glucose metabolism, which may lead to increased trans epidermal water loss, decreased skin moisture content, and increased skin oil content. CONCLUSION: The skin microbiota diversity of patients with back acne is low, and high-abundance bacteria are closely related to glucose metabolism, which may lead to the breakdown of the skin barrier and increased sebum secretion.