Mutations in CCDC39 and CCDC40 are a major cause of primary ciliary dyskinesia with microtubule disorganisation

CCDC39 和 CCDC40 基因突变是原发性纤毛运动障碍伴微管紊乱的主要原因。

阅读：1
作者：Liu,Luke L,Fame,Ryann M,Grampa,V,Delous,M,Silbermann,F,Oyde,G,Krug,P,Filhol,E,Alessandri,JL,Sigaudy,S,Bouvier,R,Zabot,MT,Antignac,C,Gubler,M,Attié-Bitach,T,Benmerah,A,Jeanpierre,C,Saunier,S,Lu,Q,Koutroumpas,K,Boldt,K,Reeuwijk,J Van,Katsanis,N,Képès,F,Roepman,R,Ueffing,M,Russell,RB,Robson,E,Moya,E,Burgoyne,T,Chetcuti,P,Dixon,M,Hirst,R,Hogg,C,Mitchison,H,O'Callaghan,C,Onoufriadis,A,Patel,M,Rutman,A,Sheridan,E,Shoemark,A,Kunimoto,K,Yamazaki,YY,Nishida,TN,Shinohara,KS,Ishikawa,HI,Hasegawa,TH,Okanoue,TO,Hamada,HH,Noda,TN,Tamura,AT,Tsukita,ST Shoichiro,Antony,D,Becker-Heck,A,Forouhan,M,Schmidts,M,Onoufriadis,A,Shoemark,A,Dixon,M,Jackson,C,Goggin,P,Olbrich,H,O’Callaghan,C,Lucas,J,Hogg,C,Chung,EMK,Omran,H,Mitchison,HM
期刊：PLoS Biology影响因子：7.200
时间：2012起止号：2012;1(Suppl 1):P1
doi：10.1371/journal.pbio.3002323

Abstract

The subcommissural organ (SCO) is a secretory tissue located on the roof of the brain's third ventricle. A new study published in PLOS Biology finds that the SCO responds to glucose by secreting signaling molecules into the cerebrospinal fluid (CSF), thereby decreasing the local ependyma-driven CSF movement.

特别声明

1、本页面内容包含部分的内容是基于公开信息的合理引用；引用内容仅为补充信息，不代表本站立场。

2、若认为本页面引用内容涉及侵权，请及时与本站联系，我们将第一时间处理。

3、其他媒体/个人如需使用本页面原创内容，需注明“来源：[生知库]”并获得授权；使用引用内容的，需自行联系原作者获得许可。

4、投稿及合作请联系：info@biocloudy.com。