Abstract
INTRODUCTION AND IMPORTANCE: Placenta increta (PI) can mimic a rare malignant tumor called Placental-site trophoblastic tumor (PSTT) with similar laboratory and clinical findings. Histological findings can help correctly diagnose PI from rare malignant tumors of PSTT. CASE PRESENTATION: According to our knowledge, only one case of PI has been reported in the literature, each of which had different characteristics, and various aspects of this lesion still need to be clarified. We reported a case of PI mimicking PSTT in a 37-year-old female. The uniqueness of the present case was its huge size and no history of abortion compared to the PI reported in the previous study. CLINICAL DISCUSSION: Our patients' ultrasound and immunohistochemical characteristics were similar to the case reported in the study. After the complete hysterectomy, the patient's bleeding stopped completely, and the patient remained disease-free during the two-year follow-up. CONCLUSION: PI can mimic a rare malignant tumor called PSTT with similar laboratory and clinical findings (Severe bleeding). The differential diagnosis of retained placenta in patients with extensive bleeding, either after vaginal delivery or after Cesarean section or abortion, should be carefully considered from PSTT. Both diseases (PSTT and PI) are treated with hysterectomy. Histological findings can help correctly diagnose PI from rare malignant tumors of PSTT.