Abstract
BACKGROUND: Amniotic fluid embolism (AFE) is a rare and catastrophic obstetric complication that can lead to sudden cardiac arrest, respiratory distress, and disseminated intravascular coagulation. Recognizing and managing this condition promptly is crucial for improving maternal and neonatal outcomes. OBJECTIVE: This report includes two case studies describing the timely detection, prompt delivery of medical treatment, and the interdisciplinary approach essential for achieving better outcomes for mothers and children confronting with this catastrophic condition. CASE PRESENTATION: Case 1: A 39-year-old pregnant woman at 36 weeks and 5 days of gestation with central placenta previa was admitted due to antepartum hemorrhage. She developed convulsions and cardiac arrest during a cesarean section, requiring cardiopulmonary resuscitation. Laboratory tests revealed severe anemia, thrombocytopenia, coagulopathy, severe acidosis, and myocardial injury. Bedside echocardiography and CT scan identified high-risk pulmonary embolisms. Intensive care included VA-ECMO, CRRT, transcatheter arterial embolization, and mechanical thrombectomy. Histopathology confirmed amniotic fluid components making up the emboli. Case 2: A 31-year-old female was transferred following a cesarean section for central placenta previa complicated by severe hemorrhage, cardiac arrest, and pulmonary embolism. Laboratory results showed severe anemia, thrombocytopenia, significant coagulopathy, myocardial injury, and hepatic injury. Histopathology confirmed amniotic components in the embolism. Management involved extensive blood transfusions, and pulmonary thromboendarterectomy. She was discharged in improved condition. CONCLUSION: Early diagnosis and prompt intervention are crucial to optimizing outcomes for patients with amniotic fluid embolism, utilizing a comprehensive multidisciplinary approach.