Abstract
The metal binding properties of macrocyclic small molecules is a key property that drives what applications for which these ligands can be used. Pyridine modified Py(2)N(2) pyridinophane small molecules are a new class of macrocyclic small molecules, whose properties have not been explored. As a result, Zn(II) metal binding of a library of six pyridine modified Py(2)N(2) complexes are reported here. These results include (1)H NMR, log β(Zn(II)), and X-ray diffraction, which are compared to PyN(3) congeners to show that the differences in each scaffold yield markedly different metal binding properties that can be exploited in future applications.