Abstract
One significant global health issue that is present in more than 190 nations globally is routine vaccination reluctance. This study aimed to synthesize the current evidence on vaccination hesitancy and its impact on immunization coverage in pediatrics. We searched for relevant studies across four databases (Scopus, Web of Science, PubMed/EMBASE, and Cumulated Index in Nursing and Allied Health Literature). Prespecified inclusion and exclusion criteria were used to extract relevant studies while excluding irrelevant ones. We found 4,085 studies on four different databases in which 23 satisfied the inclusion and exclusion criteria. These 23 relevant studies involving 29,131 parents, guardians, and caregivers from over 30 countries met the inclusion criteria and quality assessment. Studies were assessed for risk bias using the Newcastle-Ottawa scale. Vaccination hesitancy is caused by several factors, such as cultural customs, economic reforms, perceived rumors, myths, misconceptions, physicians and other healthcare professionals, and perceived risks and problems of vaccines. These results highlight the importance of addressing demand-side factors related to socioeconomic determinants and supply-side issues such as improving health literacy, combating misinformation, ensuring clarity in communication, and promoting a consistent, evidence-based message. More observations and research should be conducted regularly to develop strategies for encouraging youngsters to receive immunizations in large quantities.