Abstract
Cannabidiol (CBD) is a naturally occurring cannabinoid isolated from Cannabis sativa. CBD has therapeutic benefit for the treatment of seizures associated with various epilepsy syndromes in children; however, data are lacking related to the use of CBD for other indications in pediatric patients. Despite this lack of clinical data, the use of CBD products as a complementary treatment for various conditions in children continues to increase. Thus, it is imperative that those involved in the care of children and adolescents are well informed with current information related to CBD use in pediatrics. This review will address the pharmacology of CBD, legal and regulatory factors, usage patterns, current efficacy data, and safety concerns related to the use of CBD in children and adolescents. Recommendations for clinicians, public health officials, and researchers are also provided to effectively manage the use of unapproved CBD products in the pediatric population.