Presence of autoantibody against two placental proteins, peroxiredoxin 3 and peroxiredoxin 4, in sera of recurrent pregnancy loss patients

Our results indicate that two placental proteins, Prx3 and Prx4, may act as new placental immune targets. Considering the role of antioxidant defense in the protection of placenta from oxidative stress, production of antibodies against peroxiredoxins 3 and 4 may introduce a new autoimmune hypothesis in RPL, which is needed to be tested in the future works.

The results indicated that RPL women may produce antibody against Peroxiredoxin 3 (Prx3) and Peroxiredoxin 4 (Prx4).