Telomerase flies the coop: the telomerase RNA component as a viral-encoded oncogene

端粒酶失控了:端粒酶RNA组分作为一种病毒编码的癌基因

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Abstract

Telomerase, the enzyme that elongates our telomeres, is crucial for cancer development based on extensive analyses of human cells, human cancers, and mouse models. New data now suggest that a viral telomerase RNA gene encoded by Marek's disease virus (MDV), an oncogenic herpesvirus of chickens, promotes tumor formation. These findings highlight the importance of telomerase in cancer and raise new questions regarding the mechanisms by which the telomerase RNA component supports tumorigenesis.

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