Abstract
Aim: Nano-hydroxyapatite (nHA) is a good nanocarrier to load (223)Ra, but the low specific activity (sp.act.) of (223)Ra@nHA limits its application in medicine. Methods: We proposed a method for preparing nHA using PEG as a template, which significantly increases the sp.act of (223)Ra@nHA and a new method to loaded (99m)Tc for in vivo tracking. Results: The nHA synthesized using PEG as a template was associated with higher sp.act for (223)Ra in comparison to nHA with identical particle size and without PEG. The nHA load (99m)Tc-MDP was associated with higher labeling rate and stability in comparison to (99m)Tc. Conclusion: All these findings suggest that using PEG as a template and (99m)Tc-MDP could be the most effective of synthetic (223)Ra/(99m)Tc@nHA.