Green synthesis and characterization of silver nanoparticles through the Piper cubeba ethanolic extract and their enzyme inhibitory activities

荜茇乙醇提取物银纳米粒子的绿色合成、表征及其酶抑制活性

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作者:Khalil Ahmad, Hafiz Muhammad Asif, Taimoor Afzal, Mohsin Abbas Khan, Muhammad Younus, Umair Khurshid, Maryem Safdar, Sohaib Saifulah, Bashir Ahmad, Abubakar Sufyan, Siddique Akber Ansari, Hamad M Alkahtani, Irfan Aamer Ansari

Conclusion

The study concluded that the P. cubeba extract, as well as its green-derived AgNPs, might prove to be a better and safer substitute for their enzyme inhibitory potential in emerging medicine and novel drug delivery techniques to improve and maintain human health.

Discussion

Analysis showed the reduction of Ag+ to Ag0 at room temperature (25°C), and the average particle size of AgNPs was in the range of 40-80 nm. Consequently, the synthesized AgNPs were evaluated for their anti-urease activity. The maximum urease inhibition of the Piper cubeba ethanolic extract was 88.5% at 5 mg conc., and of derived nanoparticles was 78.6% at 0.05 mg conc. The results were nearly similar to the control drug, i.e., thiourea (0.5 and 0.6 mM conc., respectively). Conclusion: The study concluded that the P. cubeba extract, as well as its green-derived AgNPs, might prove to be a better and safer substitute for their enzyme inhibitory potential in emerging medicine and novel drug delivery techniques to improve and maintain human health.

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