Abstract
Mosquito-borne diseases (MBDs) are a major global public health concern, accounting for 17% of infectious diseases and causing ~700,000 annual deaths. Transmitted by Aedes, Anopheles, and Culex mosquitoes, they include viral (dengue, Zika, chikungunya), parasitic (malaria, lymphatic filariasis), and zoonotic (Japanese encephalitis) pathogens. This review outlines key MBDs' clinical features, global distribution-concentrated in tropics but expanding due to climate change and urbanization-and transmission dynamics shaped by environmental (temperature, humidity) and ecological (urban breeding sites) factors. It also summarizes control strategies: vector management, vaccines (e.g., R21 for malaria, IXCHIQ for chikungunya), chemoprophylaxis, and novel technologies. Moreover, persistent challenges are covered, which include insecticide resistance and socioeconomic costs (e.g., $318 billion for Aedes-borne diseases since 1975), emphasizing the need for integrated interventions.