Abstract
Dengue fever is an acute mosquito-borne disease transmitted by Aedes mosquitoes. In this paper, dengue fever outbreaks in Guangzhou, Guangdong Province and Jinghong, Yunnan Province from July 15 to November 20, 2019 were studied to explore the effects of temperature differences and imported cases on epidemic development patterns. In response to the practical issue of missing mosquito vector data, the feasibility of using meteorological data-driven dynamic model to obtain mosquito vector data was initially validated. Cross-correlation analysis was then used to assess the strong correlation between mosquito vector data and dengue cases. The relationship between bite rate, transmission rate, incubation period, mortality rate and effective reproduction number with respect to daily mean temperature (DMT) and daily temperature difference (DTR) was established by maximum likelihood estimation. The results of sensitivity analysis showed that the most sensitive parameters to basic reproduction number were mosquito mortality and transmission rate of dengue virus between mosquito vectors and humans. The results of comparative analysis showed that the temperature difference between Guangzhou and Jinghong was the main factor contributing to the difference of dengue epidemics in the two cities, because temperature could affect the development of dengue epidemics by affecting the living habits of mosquito vectors. In addition, imported cases and the intensity of epidemic prevention measures are also important factors leading to the difference in dengue epidemics between the two places. Therefore, the key to the prevention and control of dengue fever is to implement mosquito elimination as soon as possible according to the change of temperature, raise public awareness of mosquito prevention and epidemic prevention, and strengthen the control of imported cases.