Abstract
Machine learning is now extensively implemented in medical imaging for preoperative risk stratification and post-therapeutic outcome assessment, enhancing clinical decision-making. Numerous studies have focused on predicting whether thyroid nodules are benign or malignant using a nodule-based approach, which is time-consuming, inefficient, and overlooks the impact of the peritumoral region. To evaluate the effectiveness of using the whole-thyroid as the region of interest in differentiating between benign and malignant thyroid nodules, exploring the potential application value of the entire thyroid. This study enrolled 1121 patients with thyroid nodules between February 2017 and May 2023. All participants underwent contrast-enhanced CT scans prior to surgical intervention. Radiomics features were extracted from arterial phase images, and feature dimensionality reduction was performed using the Least Absolute Shrinkage and Selection Operator (LASSO) algorithm. Four machine learning models were trained on the selected features within the training cohort and subsequently evaluated on the independent validation cohort. The diagnostic performance of whole-thyroid versus nodule-based radiomics models was compared through receiver operating characteristic (ROC) curve analysis and area under the curve (AUC) metrics. The nodule-based logistic regression model achieved an AUC of 0.81 in the validation set, with sensitivity, specificity, and accuracy of 78.6%, 69.4%, and 75.6%, respectively. The whole-thyroid-based random forest model attained an AUC of 0.80, with sensitivity, specificity, and accuracy of 90.0%, 51.9.%, and 80.1%, respectively. The AUC advantage ratios on the LR, DT, RF, and SVM models are approximately - 2.47%, 0.00%, - 4.76%, and - 4.94%, respectively. The Delong test showed no significant differences among the four machine learning models regarding the region of interest defined by either the thyroid primary lesion or the whole thyroid. There was no significant difference in distinguishing between benign and malignant thyroid nodules using either a nodule-based or whole-thyroid-based strategy for ROI outlining. We hypothesize that the whole-thyroid approach provides enhanced diagnostic capability for detecting papillary thyroid carcinomas (PTCs) with ill-defined margins.