Abstract
Demyelinating pseudotumor (DPT) is an inflammatory demyelinating disease in central nervous system, and the main pathological change is demyelination, which is rare in clinical practice. A 24-year-old female patient with systemic lupus erythematosus was admitted to our hospital with the chief complaint of bilateral lower limb numbness and fatigue. Brain MRI observed the bilateral, multiple space-occupying lesions in the brain. Thus she was diagnosed as DPT. After the treatment with prednisolone and cyclophosphamide, the above-mentioned symptoms were significantly improved. The systemic lupus erythematosus combined with the DPT is rare, which should be differentiated from other neuropsychiatric diseases (such as lupus erythematosus and intracranial tumor) and avoid unnecessary invasive procedures and treatment.