Abstract
Lupus nephritis (LN) is a common complication of systemic lupus erythematosus (SLE) and often presents as an immune complex-mediated glomerular disease. While pauci-immune crescentic glomerulonephritis (PICG) is commonly associated with antineutrophil cytoplasmic antibodies (ANCAs), its occurrence in the context of LN is rare. We report a case of an SLE patient who developed acute kidney injury due to ANCA-negative PICG. The kidney injury was severe enough to necessitate renal replacement therapy; however, the patient responded well to treatment. We also review the literature and previously reported cases of PICG in patients with SLE.