Abstract
The coexistence of systemic lupus erythematosus (SLE) and Crohn's disease (CD) is very rare. The usual sequence of occurrence is CD followed by SLE, where CD treatment with anti-tumour necrosis factor (anti-TNF) induces the latter. Here, we present a case of this rare combination but with sequence reversal. The patient was unresponsive to steroids and we achieved remission with infliximab. LEARNING POINTS: Crohn's disease complicating stable systemic lupus erythematosus is extremely rare.Although it may delay time to diagnosis, it is important to rule out other common causes such as infections and medication-induced colitis.If the patient is steroid unresponsive, infliximab might be a reasonable therapeutic alternative.