Synthesis and evaluation of 1,5-dithialaminaribiose and -triose tetravalent constructs
1,5-二硫胺基二糖和-三糖四价结构的合成与评价
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作者：Daniil Ahiadorme, Chennaiah Ande, Rafael Fernandez-Botran, David Crich
| 期刊： | Carbohydrate Research | 影响因子： | 2.400 |
| 时间： | 2023 | 起止号： | 2023 Mar:525:108781. |
| doi： | 10.1016/j.carres.2023.108781 | 研究方向： | 信号转导 |
Abstract
We report the synthesis of novel tetravalent glucoclusters containing 1,5-dithia mimetics of laminaribiose and triose. The new constructs were evaluated for their ability to inhibit anti-CR3 fluorescent staining of human neutrophils, for which they showed moderate affinity. Evaluation of the synthesized glycoclusters for their ability to inhibit anti-Dectin-1 fluorescent staining of mouse macrophages revealed little to no affinity for Dectin-1.
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