Abstract
Although Nogo-B has been studied in neural development and vascular biology, its integrative role across renal, vascular and inflammatory pathways in hypertension has not yet been systematically reviewed. Here, we synthesize emerging evidence positioning Nogo-B as a central modulator of blood pressure control. Its expression in the aldosterone-sensitive distal nephron and vascular endothelium suggests a central role in electrolyte and fluid balance, as well as vascular physiology. By bridging insights from the renal, vascular and immune systems, we position Nogo-B as an emerging contributor to blood pressure regulation and highlight its potential both as a biomarker for vascular dysfunction and as a therapeutic target in salt-sensitive and treatment-resistant hypertension.