Abstract
INTRODUCTION: In recent years, due to the increasing life expectancy and the growing popularity of nephron sparing strategies (NSS), more elderly and frail patients are undergoing Robotic-Assisted Partial Nephrectomy (RAPN) for the treatment of localized Renal Cell Carcinoma (RCC). A Single Port Approach has demonstrated itself to reduce estimated blood loss (EBL), complication rates, and length of stay (LOS). In the present study, we aim to compare perioperative and postoperative outcomes of SP RAPN and Multi Port (MP) RAPN, with a focus on elderly patients. MATERIALS AND METHODS: In the study, 293 cN0M0 RCC patients who underwent MP and SP RAPN performed at our institution from 2018 to 2024 were retrospectively reviewed. Clinical, demographic, patient, and tumor characteristics and perioperative variables were assessed across group A (<65 years old) and group B (≥65 years old) patients, as well as MP and SP cohorts. Subsequently, univariate and multivariate regression analyses were carried out, particularly for elderly patients, to evaluate the impact of selected preoperative and perioperative variables on the risk of 30-day postoperative complications. RESULTS: Clinical and demographic characteristics were similar across the MP and SP cohorts of group A and group B. The SP cohort of both group A and group B demonstrated significantly higher rates of extraperitoneal access (75.9% vs. 26.6% for group A, p < 0.001 and 81.8% vs. 26.2% for group B, p < 0.001), shorter median operative times (186 [142.8-222] min vs. 190 [153-238] min for group A, p < 0.001 and 173.5 [143-228] min vs. 206 [178-237] min for group B, p < 0.001), and shorter median LOS (0 [0-1] days vs. 2 [1-3] days for group A, p < 0.001 and 0 [0,1] days vs. 2 [2-4] days for group B, p < 0.001). Moreover, for both groups, an SP approach required significantly longer median ischemia times (21 min [18-31] vs. 20 min [16-24] for group A, p = 0.02 and 24.5 min [20-28] vs. 19.5 min [16-26] for group B, p = 0.03). However, the SP cohort of group B, despite the lower rate of on-clamp procedures (63.4% vs. 90.5%, p = 0.03), demonstrated significantly lower median EBL (50 mL [31-142] vs. 100 mL [50-200], p = 0.03). At multivariate analysis, the SP approach was an independent predictor of lower 30-day postoperative complications (OR: 0.2, 95%CI 0.04-0.9, p = 0.04). CONCLUSIONS: In the present study, elderly patients undergoing SP RAPN did not demonstrate higher complication rates, EBL or hospitalization days compared to their younger counterparts. Moreover, an SP approach was found protective for 30-day postoperative complications. Our results suggest that SP RAPN is feasible and safe in older and frailer patients.