Abstract
Background: The advent of artificial intelligence (AI) has revolutionised many fields in healthcare. More recently, it has garnered interest in terms of its potential applications in histopathology, where algorithms are increasingly being explored as adjunct technologies that can support pathologists in diagnosis, molecular typing and prognostication. While many research endeavours have focused on solid tumours, gynaecological malignancies have nevertheless been relatively overlooked. The aim of this review was therefore to provide a summary of the status quo in the field of AI in gynaecological pathology by encompassing malignancies throughout the entirety of the female reproductive tract rather than focusing on individual cancers. Methods: This narrative/scoping review explores the potential application of AI in whole slide image analysis in gynaecological histopathology, drawing on both findings from the research setting (where such technologies largely remain confined), and highlights any findings and/or applications identified and developed in other cancers that could be translated to this arena. Results: A particular focus is given to ovarian, endometrial, cervical and vulval/vaginal tumours. This review discusses different algorithms, their performance and potential applications. Conclusions: The effective application of AI tools is only possible through multidisciplinary co-operation and training.