Abstract
Liposarcoma is a common occurrence over retroperitoneum. However, dedifferentiated liposarcoma is an uncommon variety affecting the small bowel mesentery, making it a rarity. We report a case of 56-year-old male presented with the lump in the abdomen. Computed tomography abdomen revealed well-defined space-occupying lesion. Laparotomy was done and mass was excised along with segment of ileum to achieve negative margin. Histopathology and immunohistochemical study helped in determining mass to be dedifferentiated liposarcoma of mesentery. Therefore, liposarcoma should be considered in differential diagnosis of abdominal mesenchymal tumors. Surgical resection to achieve negative margin is the mainstay of treatment for mesenteric liposarcomas.