Abstract
INTRODUCTION AND IMPORTANCE: Tripe palms (TP) and acanthosis nigricans (AN) are rare paraneoplastic dermatoses strongly associated with underlying malignancies, particularly gastric and lung carcinoma. Here, we report a case highlighting this uncommon dermatological manifestation as a marker of gastric carcinoma. CASE PRESENTATION: We report a case of 47-year-old man who presented with progressive hyperpigmented, hyperkeratotic cutaneous lesions consistent with TP and AN. Further evaluation revealed gastric adenocarcinoma with nodal metastasis, confirmed by histopathology and positron emission tomography - computed tomography. Following neoadjuvant chemotherapy and partial gastrectomy, he demonstrated both clinical and marked regression of cutaneous manifestations. DISCUSSION: TP and AN may serve as early paraneoplastic markers. CONCLUSION: Early recognition of paraneoplastic cutaneous manifestation can provide an early clue to internal malignancy, warranting prompt evaluation and timely treatment for better outcomes.