Abstract
Herpes simplex esophagitis (HSE) caused by herpes simplex virus (HSV) infection is a well-recognized opportunistic infection in an immunocompromised host. HSE in immunocompetent patients is an uncommon clinical event; however, when it does occur, it is generally a self-limiting condition. This case involves an immunocompetent 19-year-old female patient who presented to the emergency department (ED) with a three-day history of nausea, vomiting, and inability to tolerate oral intake. The diagnosis of HSE was made via histopathological analysis and HSV-1 polymerase chain reaction (PCR) of an esophageal biopsy. The patient clinically improved on acyclovir. HSE in the immunocompetent patient is a rare clinical entity. A combination of history, upper endoscopy, histopathology, and HSV-PCR is used to diagnose HSE. Antiviral therapy with acyclovir may reduce the severity and duration of infection.