Development of a Visual Assay for Detection of Viable Cronobacter sakazakii Using RT-PSR and Hydroxynaphthol Blue Indicator

利用RT-PSR和羟基萘酚蓝指示剂开发一种检测活阪崎肠杆菌的可视化检测方法

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Abstract

Cronobacter sakazakii is a foodborne pathogen in powdered infant formula, which poses a significant risk to susceptible populations such as infants and the elderly. This study aims to develop a visual detection method for viable C. sakazakii using the reverse transcription-polymerase spiral reaction and hydroxynaphthol blue indicator. Under the optimized conditions, the detection process could be completed within 55 min with low equipment dependence. It was evaluated to have high specificity and sensitivity with the detection limit low to 1.2 × 10(1) CFU/mL. The assay also showed 100% accuracy in artificially contaminated samples.

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