Abstract
CD8(+)T cell exhaustion is a state of T cell dysfunction during chronic infection and tumor progression. Exhausted CD8(+)T cells are characterized by low effector function, high expression of inhibitory receptors, unique metabolic patterns, and altered transcriptional profiles. Recently, advances in understanding and interfering with the regulatory mechanisms associated with T cell exhaustion in tumor immunotherapy have brought greater attention to the field. Therefore, we emphasize the typical features and related mechanisms of CD8(+)T cell exhaustion and particularly the potential for its reversal, which has clinical implications for immunotherapy.