Abstract
Constrictive pericarditis is a result of chronic inflammation characterized by thickening and calcification of pericardial fibers, impaired diastolic filling, reduced cardiac output, and ultimately heart failure. The main objective of this multicenter trial is to evaluate whether conventional extracorporeal circulation pericardial resection has a better prognosis than pericardial resection without extracorporeal circulation. This study is a multicenter, randomized controlled, evaluator blinded, parallel group study with an advantageous framework. A total of 436 participants with constrictive pericarditis will be randomly assigned to either the extracorporeal circulation pericardial resection group or the non-extracorporeal circulation pericardial clearance group in a 1:1 ratio using a computer. Incomplete pericardial detachment is associated with low cardiac output syndrome after pericardial resection. The causes of low cardiac output syndrome are related to incomplete resection of thickened pericardium, unsatisfactory relief of left ventricular compression, excessive ventricular dilation after pericardial dissection, myocardial weakness, and heart failure. The relief of left ventricular compression is crucial for the postoperative recovery of cardiac function.