Abstract
BACKGROUND: The advent of flow diverters (FDs) has revolutionized the treatment of intracranial aneurysms. The Lattice Flow Diverter (LFD) is a novel, domestically developed FD in China. To date, no clinical reports have described the use of the LFD in treating small and medium-sized intracranial aneurysms. In this study, we aimed to evaluate the safety and efficacy of the LFD in the treatment of small and medium-sized aneurysms in the anterior circulation. METHODS: We retrospectively reviewed patients with small or medium-sized anterior circulation aneurysms who underwent LFD implantation at Jingmen People's Hospital between September 2023 and May 2025. Demographic data, aneurysm morphology, and procedural details were collected from complete clinical and imaging records. Periprocedural neurological complications, angiographic outcomes, and clinical follow-up results were systematically analyzed. RESULTS: A total of 56 patients were included. Among 56 patients, nine patients (16.1%) underwent adjunctive coil embolization. Two patients (3.6%) experienced periprocedural complications, both minor ischemic strokes. During a mean clinical follow-up of 7.18 months, complete occlusion (OKM grade D) was achieved in 71.4% of aneurysms, and adequate occlusion (OKM grades C + D) in 85.7%. All patients had a favorable clinical outcome (mRS score 0-2). Subgroup analysis showed no statistically significant differences in complete or successful occlusion rates between patients treated with LFD alone and those treated with LFD combined with coil embolization (p > 0.05). CONCLUSION: Our study preliminarily suggests that the use of the LFD for small and medium-sized anterior circulation aneurysms is associated with acceptable periprocedural safety and favorable short term angiographic and clinical outcomes. Further large-scale, multicenter, prospective studies are required to validate these findings.