CLEC5A is critical for dengue virus-induced osteoclast activation and bone homeostasis
CLEC5A 对登革热病毒诱导的破骨细胞活化和骨稳态至关重要
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作者：Ya-Lang Huang, Szu-Ting Chen, Ren-Shyan Liu, Yen-Hsu Chen, Chun-Yu Lin, Chung-Hao Huang, Pei-Yun Shu, Ching-Len Liao, Shie-Liang Hsieh
Key messages
Cultured osteoclasts were susceptible to DV infection. Osteoclasts produced similar amounts of cytokines and infectious virions as macrophages. DV induced nuclear translocation of NFATc1 in osteoclast via CLEC5A. DV caused transient inflammatory reaction in bone tissue and upregulated osteolytic activity. Antagonistic anti-CLEC5A mAb inhibited DV-activated osteolytic activity in vivo.
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