Abstract
OBJECTIVE: To summarize the research progress of interfacial tissue engineering in rotator cuff repair. METHODS: The recent literature at home and abroad concerning interfacial tissue engineering in rotator cuff repair was analysed and summarized. RESULTS: Interfacial tissue engineering is to reconstruct complex and hierarchical interfacial tissues through a variety of methods to repair or regenerate damaged joints of different tissues. Interfacial tissue engineering in rotator cuff repair mainly includes seed cells, growth factors, biomaterials, oxygen concentration, and mechanical stimulation. CONCLUSION: The best strategy for rotator cuff healing and regeneration requires not only the use of biomaterials with gradient changes, but also the combination of seed cells, growth factors, and specific culture conditions (such as oxygen concentration and mechanical stimulation). However, the clinical transformation of the relevant treatment is still a very slow process.