Abstract
The development of glucose sensors for continuous glucose monitoring (CGM) is likely still in its early days. A number of novel approaches-along with many attempts to improve current CGM systems-are in development. The next generation of glucose sensors (NGGS) will also enable, for example, reliable glucose measurement in the low glycemic range. NGGS systems represent an important step forward for closed-loop systems. This commentary discusses a number of aspects that are relevant in this context.