Abstract
BACKGROUND: Structural and functional alterations in the cerebellum have been consistently reported in addiction literatures. However, evidence implicating the resting-state cerebellar-cerebral functional connectivity in methamphetamine (MA) use disorder still remains limited. METHODS: Resting-state functional magnetic resonance imaging (fMRI) scans were obtained from 34 MA dependent individuals with about six months abstinence and 31 healthy controls (well matched for age, gender and education) in this study. Seed-based functional connectivity analysis was employed to investigate the differences in cerebellar-cerebral functional connectivity between two groups. The correlations between significant functional connectivity and each clinical characteristic were also explored. RESULTS: Compared to healthy controls, MA dependent individuals showed disrupted functional connectivity between the cerebellum and several cerebral functional networks, including the default-mode, affective-limbic, and sensorimotor networks. Within the MA group, functional connectivity of the right cerebellar lobule VI-precuneus coupling was negatively correlated with addiction severity. CONCLUSION: The present study suggests that cerebellar dysfunction, in particular aberrant cerebellar-cerebral functional connectivity, might involve in neurobiological mechanism of MA dependence, which supply a potential target for therapeutic interventions in the future.