Characterization of a NIR absorbing thienyl curcumin contrast agent for photoacoustic imaging

对一种用于光声成像的近红外吸收噻吩基姜黄素对比剂进行表征

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Abstract

The synthesis and characterization of a bis(2-dimethylaminothien-5-yl)curcumin boron difluoride chromophore is presented. Photophysical, electrochemical and computational investigations establish the properties of its absorption in the Vis-NIR spectral range relative to established curcumin dyes. Application of this thienyl curcumin dye as a photoacoustic contrast agent is investigated against the dicarbocyanine Cy5 dye in the 675-735 nm excitation range.

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